AKI-001

• Description:

  AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes[1].

• UNSPSC:

  12352005

• Target:

  Aurora Kinase

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3

• Molecular Formula:

  C21H24N4O

• Molecular Weight:

  348.44

• References & Citations:

  [1]Rawson, T. E., et al., (2008) . A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of medicinal chemistry, 51 (15), 4465-4475.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [925218-37-7]