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Atiprosine

CAT: 0804-HY-119854Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119854Size:1 Each
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Description
Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor) . The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.
CAS Number
89303-63-9
Product Name Alternative
AY-28228
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
CC(C)N1CCN([C@@]2([C@@]1(CCN3C2=C(C4=C3C=CC=C4)C)[H])[H])CC
Molecular Formula
C20H29N3
Molecular Weight
311.46
References & Citations
[1]Oshiro G, et al. Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys. J Cardiovasc Pharmacol. 1987 Sep;10 (3) :341-9.|[2]Grimes D, et al. In vitro isolated tissue studies with atiprosin (AY-28,228) : a new antihypertensive compound. J Cardiovasc Pharmacol. 1987 Sep;10 (3) :249-58.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; H1 Receptor; α adrenergic receptor

Alternative Products

CatalogName
GTR19274060-01Atiprosine

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