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Tetradifon

CAT: 0804-HY-119725-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119725-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg2+-stimulated ATPase, with an IC50 of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants[1][2][3][4][5].
CAS Number
116-29-0
UNSPSC
12352005
Hazard Statement
H302-H410
Target
Insecticide
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=C(C=C(C(Cl)=C1)Cl)Cl)(C2=CC=C(C=C2)Cl)=O
Molecular Formula
C12H6Cl4O2S
Molecular Weight
356.05
Precautions
P264-P270-P273-P330-P391-P501
References & Citations
[1]Desaiah D, et al. Tetradifon (tedion R) : a specific inhibitor of Mg 2+ dependent mitochondrial adenosine triphosphatase activity. Life Sci II. 1972 Apr 8;11 (7) :389-95.|[2]Bustamante E, et al. Tetradifon: an oligomycin-like inhibitor of energy-linked activities of rat liver mitochondria. Biochem Biophys Res Commun. 1973 Mar 17;51 (2) :292-8.|[3]Badraoui R, et al. Effect of subchronic exposure to tetradifon on bone remodelling and metabolism in female rat. C R Biol. 2007 Dec;330 (12) :897-904.|[4]Badraoui R, et al. Nephrotoxic effect of tetradifon in rats: a biochemical and histomorphometric study. Exp Toxicol Pathol. 2012 Sep;64 (6) :645-50.|[5]Fatemeh Ganjeizadeh Rohani, et al. Electropolymerized MIP With MWCNTs on Stir Bar Using Multivariate Optimization for Tetradifon Detection in Date. Pharm Nanotechnol. 2019;7 (5) :404-417.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mite

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