J-30

• Description :

  J-30 is an orally active and potent tubulin inhibitor (IC50=15-20 nM) . J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral) [1].

• UNSPSC :

  12352005

• Target :

  Microtubule/Tubulin

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CC=NC=C1)NC2=CC=CC3=C2N(CC3)S(=O)(C4=CC=C(C=C4)OC)=O

• Molecular Formula :

  C21H19N3O4S

• Molecular Weight :

  409.46

• References & Citations :

  [1]Liou JP, et al. A novel oral indoline-sulfonamide agent, N-[1- (4-methoxybenzenesulfonyl) -2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther. 2007 Oct;323 (1) :398-405.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [916484-16-7]