Sulfoxaflor-d3

• Description:

  Sulfoxaflor-d3 is the deuterium labeled Sulfoxaflor (HY-118504) . Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A) . Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc[1][2].

• UNSPSC:

  12352211

• Target:

  Isotope-Labeled Compounds; nAChR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Field of Research:

  Neurological Disease

• Smiles:

  O=S(C(C1=CC=C(N=C1)C(F)(F)F)C([2H])([2H])[2H])(C)=NC#N

• Molecular Formula:

  C10H7D3F3N3OS

• Molecular Weight:

  280.28

• References & Citations:

  [1]Jean-Noël Houchat, et al. Mode of Action of Sulfoxaflor on α-bungarotoxin-insensitive nAChR1 and nAChR2 Subtypes: Inhibitory Effect of Imidacloprid. Neurotoxicology. 2019 Sep;74:132-138.|[2]Siviter H, et al. Sulfoxaflor exposure reduces bumblebee reproductive success. Nature. 2018 Sep;561 (7721) :109-112.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported