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Sulfoxaflor-d3

CAT: 0804-HY-118504SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118504SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulfoxaflor-d3 is the deuterium labeled Sulfoxaflor. Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc[1][2].
UNSPSC
12352211
Target
Isotope-Labeled Compounds; nAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=S(C(C1=CC=C(N=C1)C(F)(F)F)C([2H])([2H])[2H])(C)=NC#N
Molecular Formula
C10H7D3F3N3OS
Molecular Weight
280.28
References & Citations
[1]Jean-Noël Houchat, et al. Mode of Action of Sulfoxaflor on α-bungarotoxin-insensitive nAChR1 and nAChR2 Subtypes: Inhibitory Effect of Imidacloprid. Neurotoxicology. 2019 Sep;74:132-138.|[2]Siviter H, et al. Sulfoxaflor exposure reduces bumblebee reproductive success. Nature. 2018 Sep;561 (7721) :109-112.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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