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Sulfoxaflor

CAT: 0804-HY-118504-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118504-01Size:5 mg
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Description
Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine , but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc[1][2].
CAS Number
946578-00-3
Product Name Alternative
PCR 5332
UNSPSC
12352005
Hazard Statement
H302, H400, H410
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sulfoxaflor.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(C(F)(F)F)N=C1)S(=NC#N)(C)=O
Molecular Formula
C10H10F3N3OS
Molecular Weight
277.27
Precautions
H302, H400, H410
References & Citations
[1]Jean-Noël Houchat, et al. Mode of Action of Sulfoxaflor on α-bungarotoxin-insensitive nAChR1 and nAChR2 Subtypes: Inhibitory Effect of Imidacloprid. Neurotoxicology. 2019 Sep;74:132-138.|[2]Siviter H, et al. Sulfoxaflor exposure reduces bumblebee reproductive success. Nature. 2018 Sep;561 (7721) :109-112.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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