Sulfoxaflor

• Description:

  Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A) . Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc[1][2].

• Product Name Alternative:

  PCR 5332

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H400, H410

• Target:

  NAChR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sulfoxaflor.html

• Purity:

  99.92

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC(C1=CC=C(C(F)(F)F)N=C1)S(=NC#N)(C)=O

• Molecular Formula:

  C10H10F3N3OS

• Molecular Weight:

  277.27

• Precautions:

  H302, H400, H410

• References & Citations:

  [1]Jean-Noël Houchat, et al. Mode of Action of Sulfoxaflor on α-bungarotoxin-insensitive nAChR1 and nAChR2 Subtypes: Inhibitory Effect of Imidacloprid. Neurotoxicology. 2019 Sep;74:132-138.|[2]Siviter H, et al. Sulfoxaflor exposure reduces bumblebee reproductive success. Nature. 2018 Sep;561 (7721) :109-112.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [946578-00-3]