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DFL23448

CAT: 0804-HY-117372Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117372Size:1 Each
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Description
DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC50 values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC50 >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats[1].
CAS Number
1445753-16-1
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
OC1=C(C2=NN(CC)N=N2)SC(C3=CC=CC(F)=C3)=N1
Molecular Formula
C12H10FN5OS
Molecular Weight
291.30
References & Citations
[1]Mistretta FA, et al. DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats. J Pharmacol Exp Ther. 2016 Jan;356 (1) :200-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM8

Alternative Products

CatalogName
MBS5813172DFL23448

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