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D156844 (hydrochloride)

CAT: 0804-HY-117000ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117000ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research[1].
UNSPSC
12352100
Target
Dihydrofolate reductase (DHFR) ; DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Smiles
NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1.[H]Cl.[H]Cl
Molecular Formula
C21H26Cl2FN5O
Molecular Weight
454.37
References & Citations
[1]Thurmond J, et al. Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem. 2008 Feb 14;51 (3) :449-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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