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Nimbolide (Standard)

CAT: 0804-HY-116035RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116035RSize:1 Each
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Description
Nimbolide (Standard) is the analytical standard of Nimbolide. This product is intended for research and analytical applications. Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1][2].
CAS Number
25990-37-8
UNSPSC
12352100
Target
Apoptosis; CDK; NF-κB; Reference Standards; Wnt
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; NF-κB; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
C[C@]12[C@@]3([H])[C@](OC([C@@]3(C=CC2=O)C)=O)([H])[C@]4([H])[C@]([C@@H]1CC(OC)=O)(C5=C(C)[C@@](C6=COC=C6)([H])C[C@@]5([H])O4)C
Molecular Formula
C27H30O7
Molecular Weight
466.52
References & Citations
[1]Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28 (5) :1026-35.|[2]Karkare S, et al. Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth. Clin Cancer Res. 2014 Jan 1;20 (1) :199-212.|[3]lumalai P, Arunkumar R, Benson CS, Sharmila G, Arunakaran J. Nimbolide inhibits IGF-I-mediated PI3K/Akt and MAPK signalling in human breast cancer cell lines (MCF-7 and MDA-MB-231) . Cell Biochem Funct. 2014 Jul;32 (5) :476-84.|[4]Lin H, Qiu S, Xie L, Liu C, Sun S. Nimbolide suppresses non-small cell lung cancer cell invasion and migration via manipulation of DUSP4 expression and ERK1/2 signaling. Biomed Pharmacother. 2017 Aug;92:340-346.|[5]Gupta SC, Prasad S, Sethumadhavan DR, Nair MS, Mo YY, Aggarwal BB. Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment. Clin Cancer Res. 2013 Aug 15;19 (16) :4465-76.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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