WAY-123783

• Description:

  WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg) . WAY-123783 can be used for the research of metabolic disease, such as diabetes[1][2].

• UNSPSC:

  12352005

• Target:

  SGLT

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C1NNC(C(F)(F)F)=C1CC2=CC=C(C=C2)SC

• Molecular Formula:

  C12H11F3N2OS

• Molecular Weight:

  288.29

• References & Citations:

  [1]Ohsumi K, Matsueda H, Hatanaka T, Hirama R, Umemura T, Oonuki A, Ishida N, Kageyama Y, Maezono K, Kondo N. Pyrazole-O-glucosides as novel Na (+) -glucose cotransporter (SGLT) inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2269-72.|[2]Kees KL, et al. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl) pyrazoles and -pyrazolones. J Med Chem. 1996 Sep 27;39 (20) :3920-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SGLT2

• CAS Number:

  [152595-59-0]