BC-1485

• Description :

  BC-1485 is a small molecule inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1) . BC-1485 protects PIAS4 from ubiquitin-mediated degradation. BC-1485 decreases α-SMA, BAL and CXCL1. BC-1485 ameliorates fibrotic lung injury in murine models[1][2].

• UNSPSC :

  12352005

• Target :

  CXCR

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Field of Research :

  Others

• Smiles :

  O=C(NC(C)C(N(C)C)=O)C1=CC=C(NS(=O)(C2=CC=C(N3)C(NC3=O)=C2)=O)C=C1

• Molecular Formula :

  C19H21N5O5S

• Molecular Weight :

  431.47

• References & Citations :

  [1]Lear T, et al. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30;213 (6) :1029-46.|[2]Lear T, et al. Therapeutic targets in fibrotic pathways. Cytokine. 2016 Dec;88:193-195.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CXCR1

• CAS Number :

  [2035085-19-7]