BC-1485

• Description:

  BC-1485 is a small molecule inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1) . BC-1485 protects PIAS4 from ubiquitin-mediated degradation. BC-1485 decreases α-SMA, BAL and CXCL1. BC-1485 ameliorates fibrotic lung injury in murine models[1][2].

• UNSPSC:

  12352005

• Target:

  CXCR

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Field of Research:

  Others

• Smiles:

  O=C (NC (C) C (N (C) C) =O) C1=CC=C (NS (=O) (C2=CC=C (N3) C (NC3=O) =C2) =O) C=C1

• Molecular Formula:

  C19H21N5O5S

• Molecular Weight:

  431.47

• References & Citations:

  [1]Lear T, et al. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30;213 (6) :1029-46.|[2]Lear T, et al. Therapeutic targets in fibrotic pathways. Cytokine. 2016 Dec;88:193-195.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CXCR1

• CAS Number:

  2035085-19-7