Products for Research Use Only
RegisterLogin

7-Ketocholesterol (Standard)

CAT: 0804-HY-113342R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-113342R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
7-Ketocholesterol (Standard) is the analytical standard of 7-Ketocholesterol. This product is intended for research and analytical applications. 7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) [1].
CAS Number
566-28-9
UNSPSC
12352100
Target
Endogenous Metabolite; p38 MAPK; Reference Standards
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCCC(C)C)([H])[C@@](C(C=C3C[C@H]4O)=O)([H])[C@@]2([H])[C@]3(CC4)C
Molecular Formula
C27H44O2
Molecular Weight
400.64
References & Citations
[1]M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31 (3-4) :369-75. |[2]Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380.|[3]Amaral J, et al. 7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model. PLoS One. 2013;8 (2) :e56099.|[4]Tani M, et al. 7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway. PLoS One. 2018 Jul 31;13 (7) :e0200499.|[5]Luthra S, et al. 7-Ketocholesterol activates caspases-3/7, -8, and-12 in human microvascular endothelial cells in vitro[J]. Microvascular research, 2008, 75 (3) : 343-350.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-113342-017-Ketocholesterol
HY-N7264R7α-Hydroxycholesterol (Standard)
HY-133091R-017-Ethoxycoumarin (Standard)
HY-113279R-017-Dehydrocholesterol (Standard)
HY-131580R7-Ethyltryptophol (Standard)
HY-113352R7-Methylguanine (Standard)
HY-N2108R-017-Ethylcamptothecin (Standard)
HY-N7108R-017-Hydroxyflavone (Standard)
HY-34763R-017-Hydroxycarbostyril (Standard)
HY-N8487R7-Methoxyflavone (Standard)

Alternative Products

CatalogName
A3613PH 7.0 Standard
CALMIX7-500ICP Instrument Check Standard 7
Z655139-500MLHanna pH 7.010 Standard
QC-7-01ICP Quality Control Standard 7
1213843Whirl-Pak® Standard Sachets 7
GARD071Reagecon Gardner 7 Colour Standard
PH-BUFF7-500PH 7 Buffer Standard 500mL
P2307pH Standard solution, pH 7.0
40120195-1TBS Standard 10X, pH 7.4
140-2003-D7-Component Organic Standard (Spain) - EACH

Popular Products