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3-Methyluridine (Standard)

CAT: 0804-HY-113138RSize: 1 EachDry Ice: NoHazardous: No
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Description
3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance[1][2][3].
CAS Number
2140-69-4
UNSPSC
12352100
Target
Endogenous Metabolite; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Smiles
O[C@H]1[C@@H](O)[C@H](N(C(N2C)=O)C=CC2=O)O[C@@H]1CO
Molecular Formula
C10H14N2O6
Molecular Weight
258.23
References & Citations
[1]Rohan T Ranasinghe, et al. Detecting RNA base methylations in single cells by in situ hybridization. Nat Commun|[2]Desaulniers JP, et al. Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine. Bioorg Med Chem. 2005 Dec 15;13 (24) :6777-81.|[3]Chui HM, et al. Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. Bioorg Med Chem. 2002 Feb;10 (2) :325-32.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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