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3-Methyluridine

CAT: 0804-HY-113138-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113138-01Size:5 mg
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Description
3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance[1][2][3].
CAS Number
2140-69-4
Product Name Alternative
N3-Methyluridine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-Methyluridine.html
Purity
99.05
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N(C(N2C)=O)C=CC2=O)O[C@@H]1CO
Molecular Formula
C10H14N2O6
Molecular Weight
258.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Rohan T Ranasinghe, et al. Detecting RNA base methylations in single cells by in situ hybridization. Nat Commun|[2]Desaulniers JP, et al. Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine. Bioorg Med Chem. 2005 Dec 15;13 (24) :6777-81.|[3]Chui HM, et al. Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. Bioorg Med Chem. 2002 Feb;10 (2) :325-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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