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SSM3 (tetraTFA hydrate)

CAT: 0804-HY-110147BSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110147BSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2].
UNSPSC
12352005
Target
Furin
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.29
Solubility
DMSO : 30 mg/mL (ultrasonic)
Smiles
N=C(N)NC(C=C1)=CC=C1O[C@@H]2[C@H](C[C@@H](NC(N)=N)[C@H](OC3=CC=C(NC(N)=N)C=C3)C2)NC(N)=N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.O.[1.5]
Molecular Formula
C30H36F12N12O10.1.5H2O
Molecular Weight
979.70
References & Citations
[1]Albert G Remacle, et al. Selective and Potent Furin Inhibitors Protect Cells From Anthrax Without Significant Toxicity. Int J Biochem Cell Biol.|[2]Guan-Sheng Jiao, et al. Synthetic Small Molecule Furin Inhibitors Derived From 2,5-dideoxystreptamine. Proc Natl Acad Sci U S A. 2006 Dec 26;103 (52) :19707-12.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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