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Vadimezan (Standard)

CAT: 0804-HY-10964R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10964R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vadimezan (Standard) (DMXAA (Standard) ) is the analytical standard of Vadimezan. This product is intended for research and analytical applications. Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.
CAS Number
117570-53-3
Product Name Alternative
DMXAA (Standard) ; ASA-404 (Standard)
UNSPSC
12352005
Target
IFNAR; Influenza Virus; Reference Standards; STING
Related Pathways
Anti-infection; Immunology/Inflammation; Others
Field of Research
Cancer; Infection
Smiles
O=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
Molecular Formula
C17H14O4
Molecular Weight
282.29
References & Citations
[1]Downey CM, et al. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One. 2014 Jun 18;9 (6) :e99988.|[2]Shirey KA, et al. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo. J Leukoc Biol. 2011 Mar;89 (3) :351-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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