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Camsirubicin

CAT: 0804-HY-109113Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109113Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Camsirubicin (GPX-150) is a non-cardiotoxic Doxorubicin analog that selectively targets topoisomerase IIβ. Camsirubicin reduces cell viability and clone formation of MDA-MB-468 breast cancer cells. Camsirubicin increases the exposure of CALR and HSP90 on the cell surface. Camsirubicin can be used for the study of breast cancer[1][2].
CAS Number
236095-26-4
Product Name Alternative
GPX-150
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=C(C[C@](CCO)(O)C[C@@H]2O[C@@](O[C@@H](C)[C@H]3O)([H])C[C@@H]3N)C2=C(O)C(C4=N)=C1C(C5=CC=CC(OC)=C45)=O
Molecular Formula
C27H32N2O9
Molecular Weight
528.55
References & Citations
[1]Frank NE, et al. Comparative effects of doxorubicin and a doxorubicin analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on human topoisomerase IIβ activity and cardiac function in a chronic rabbit model. Invest New Drugs. 2016 Dec;34 (6) :693-700. |[2]Xinxin Song, et al. Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers. Cancer Discov. 2020 Dec;10 (12) :1872-1893.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Topo II

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