Camsirubicin HCl

CAT: 0931-T69669-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T69669-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

236095-24-2

Target

Others

Related Pathways

Others

Bioactivity

Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.

Smiles

OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](CCO)(O)C2)C(O)=C4C1C(=O)C=5C(C4=N)=C(OC)C=CC5.Cl

Molecular Formula

C27H33ClN2O9

Molecular Weight

565.01

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

GPX-150 hydrochloride

CAS Number	236095-24-2
PubChem CID	135446068
IUPAC Name	(8R,10S)-10-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-9,10-dihydro-7H-tetracen-5-one;hydrochloride
Molecular Formula	C27H33ClN2O9
Molecular Weight	565.0
Topological Polar Surface Area	196
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Heavy Atom Count	39
Formal Charge	0
Complexity	906

SMILES

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=N)C(=CC=C5)OC)O)(CCO)O)N)O.Cl

InChI

InChI=1S/C27H32N2O9.ClH/c1-11-23(31)14(28)8-17(37-11)38-16-10-27(35,6-7-30)9-13-19(16)26(34)20-21(25(13)33)24(32)12-4-3-5-15(36-2)18(12)22(20)29;/h3-5,11,14,16-17,23,29-31,33-35H,6-10,28H2,1-2H3;1H/t11-,14-,16-,17-,23+,27-;/m0./s1

InChIKey

QVPRMGHPBJJSRU-IGAJXZAQSA-N

Chemical Structure

2D Structure

CAS: 236095-24-2

CID: 135446068

Formula: C27H33ClN2O9

MW: 565.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	565.0
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	5
Exact Mass	564.1874583
Monoisotopic Mass	564.1874583
Topological Polar Surface Area	196 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	906
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Camsirubicin HCl

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