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D-87503

CAT: 0804-HY-108959Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108959Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-87503 is a potent inhibitor of PI3k/Akt/mTOR, with the IC50s of 62 nM and 0.76 μM, respectively for PI3k and Erk2. D-87503 effectively suppressed the target downstream substrates Akt and Rsk1 kinase of the PI3k/Akt/mTOR signaling pathway[1].
CAS Number
800394-83-6
UNSPSC
12352005
Target
ERK; mTOR; PI3K
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
S=C(NCC=C)NC1=CC=C2C(N=C(C3=CC=C(O)C=C3)C=N2)=N1
Molecular Formula
C17H15N5OS
Molecular Weight
337.40
References & Citations
[1]Mukesh Chandra Joshi, et al. Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology. Review Curr Drug Discov Technol. 2014 Jun;11 (2) :113-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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