Morphothiadin (mesylate)

• Description:

  Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir (HY-B1826) -resistant HBV replication with an IC50 value of 12 nM[1][2].

• Product Name Alternative:

  GLS4 (mesylate)

• UNSPSC:

  12352005

• Target:

  HBV

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C(C1=C(CN2CCOCC2)N=C(C3=NC=CS3)NC1C4=CC=C(C=C4Br)F)OCC.O=S(O)(C)=O

• Molecular Formula:

  C22H26BrFN4O6S2

• Molecular Weight:

  605.50

• References & Citations:

  [1]Zhou X, et al. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacol Sin. 2013 Nov;34 (11) :1420-6. |[2]Wu G, et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57 (11) :5344-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [1646361-04-7]