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JNK-9L

CAT: 0804-HY-10851-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10851-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC50s of 0.099 and 0.148 μM for JNK1 and JNK3, respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin -induced ROS generation with an IC50 of 0.8 nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research[1].
CAS Number
1128096-64-9
UNSPSC
12352005
Target
JNK; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
98.06
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC(C2=NC(NC(C=C3)=CC=C3N4C=NC(N5CCOCC5)=N4)=NC=C2)=CC(N6CCOCC6)=C1
Molecular Formula
C26H27FN8O2
Molecular Weight
502.54
References & Citations
[1]Kamenecka T, et al. Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors. J Med Chem. 2010 Jan 14;53 (1) :419-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK3

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