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AG126 (Standard)

CAT: 0804-HY-108330RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108330RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AG126 (Standard) is the analytical standard of AG126. This product is intended for research and analytical applications. AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].
CAS Number
118409-62-4
UNSPSC
12352100
Target
ERK; Mitosis; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
N#C/C(C#N)=C/C1=CC=C([N+]([O-])=O)C(O)=C1
Molecular Formula
C10H5N3O3
Molecular Weight
215.17
References & Citations
[1]Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157 (1) :145-58.|[2]Garg TK, et al. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5.|[3]Dugo L, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Intensive Care Med. 2002 Jun;28 (6) :775-88.|[4]Bullard LE, et al. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr;44 (4) :1722-31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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