AG126

CAT: 0931-T4092-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T4092-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

118409-62-4

Target

COX, ERK

Related Pathways

Immunology/Inflammation, MAPK, Neuroscience

Purity

0.9872

Bioactivity

AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM) .

Smiles

Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O

Molecular Formula

C10H5N3O3

Molecular Weight

215.16

Shipping Conditions

Ice Packs

Storage Temperature

-20°C