Raltitrexed (Standard)

• Description:

  Raltitrexed (Standard) is the analytical standard of Raltitrexed. This product is intended for research and analytical applications. Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.

• UNSPSC:

  12352100

• Target:

  Nucleoside Antimetabolite/Analog; Reference Standards; Thymidylate Synthase

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Others

• Field of Research:

  Cancer

• Smiles:

  CC(NC1=O)=NC2=C1C=C(CN(C)C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)C=C2

• Molecular Formula:

  C21H22N4O6S

• Molecular Weight:

  458.49

• References & Citations:

  [1]Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23 (5) :237-48|[2]Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398 (1-2) :223-31.|[3]Xue S, et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10 (4) :1927-34.|[4]Waldman BC, et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst) . 2008 Oct 1;7 (10) :1624-35.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [112887-68-0]