Raltitrexed

• Description:

  Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.

• Product Name Alternative:

  ZD1694; D1694; ICI-D1694

• UNSPSC:

  12352005

• Hazard Statement:

  H300, H360

• Target:

  Nucleoside Antimetabolite/Analog; Thymidylate Synthase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Raltitrexed.html

• Concentration:

  10mM

• Purity:

  99.51

• Solubility:

  DMSO : ≥ 29 mg/mL

• Smiles:

  CC(NC1=O)=NC2=C1C=C(CN(C)C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)C=C2

• Molecular Formula:

  C21H22N4O6S

• Molecular Weight:

  458.49

• Precautions:

  H300, H360

• References & Citations:

  [1]Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23 (5) :237-48|[2]Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398 (1-2) :223-31.|[3]Xue S, et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10 (4) :1927-34.|[4]Waldman BC, et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst) . 2008 Oct 1;7 (10) :1624-35.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  112887-68-0