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ALM-201

CAT: 0804-HY-107131Size: 1 EachDry Ice: NoHazardous: No
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Description
ALM-201 is a peptide inhibitor of angiogenesis targeting microtubule. ALM-201 can inhibit cells migration, tubule formation and microvessel formation. ALM-201 can be used for the research of cancer[1].
CAS Number
959961-27-4
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC[C@@H]([C@H](N)C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N4CCC[C@H]4C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(O)=O)CO)=O)C)=O)=O)CC(O)=O)=O)=O)CO)=O)C(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)[C@H](O)C)=O)CCC(O)=O)=O)[C@H](O)C)=O)=O)=O)CC(O)=O)=O)CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)C
Molecular Formula
C110H179N31O40
Molecular Weight
2575.78
References & Citations
[1]O'Rourke M, et al. The anti-tumour efficacy of the novel peptide inhibitor of angiogenesis ALM-201[J]. Cancer Research, 2011, 71 (8_Supplement) : 3288-3288.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

8Eutmepn0L

ALM201 is an anti-angiogenic synthetic peptide identified from the endogenous human protein, FKBPL. It is being investigated in the treatment of various cancers.

CAS Number959961-27-4
PubChem CID172866231
IUPAC Name(4S)-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-5-[[(2S)-1-[[(2S)-4-carboxy-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-carboxy-1-[(2S)-2-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC110H179N31O40
Molecular Weight2575.8
XLogP-12.7
Topological Polar Surface Area1140
Hydrogen Bond Donor Count36
Hydrogen Bond Acceptor Count43
Rotatable Bond Count80
Heavy Atom Count181
Formal Charge0
Complexity6050
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC(=O)O)C(=O)N5CCC[C@H]5C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)O)N
InChI
InChI=1S/C110H179N31O40/c1-12-53(8)82(113)99(171)125-58(21-14-38-119-110(116)117)87(159)121-59(27-32-75(111)146)89(161)127-63(28-33-76(112)147)103(175)137-39-16-23-71(137)96(168)124-57(20-13-37-118-109(114)115)88(160)130-66(46-80(154)155)105(177)141-43-19-26-74(141)107(179)140-42-18-25-73(140)98(170)136-85(56(11)145)101(173)126-62(31-36-79(152)153)92(164)135-84(55(10)144)102(174)129-65(45-51(4)5)94(166)122-60(29-34-77(148)149)90(162)128-64(44-50(2)3)93(165)123-61(30-35-78(150)151)91(163)134-83(52(6)7)100(172)132-68(48-142)106(178)139-41-17-24-72(139)97(169)131-67(47-81(156)157)104(176)138-40-15-22-70(138)95(167)120-54(9)86(158)133-69(49-143)108(180)181/h50-74,82-85,142-145H,12-49,113H2,1-11H3,(H2,111,146)(H2,112,147)(H,120,167)(H,121,159)(H,122,166)(H,123,165)(H,124,168)(H,125,171)(H,126,173)(H,127,161)(H,128,162)(H,129,174)(H,130,160)(H,131,169)(H,132,172)(H,133,158)(H,134,163)(H,135,164)(H,136,170)(H,148,149)(H,150,151)(H,152,153)(H,154,155)(H,156,157)(H,180,181)(H4,114,115,118)(H4,116,117,119)/t53-,54-,55+,56+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,82-,83-,84-,85-/m0/s1
InChIKey
WELPKBYIJNCUBV-PSAZGCNZSA-N
Chemical Structure
2D Structure
2D structure of 8Eutmepn0L
CAS: 959961-27-4
CID: 172866231
Formula: C110H179N31O40
MW: 2575.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight2575.8
XLogP3-12.7
Hydrogen Bond Donor Count36
Hydrogen Bond Acceptor Count43
Rotatable Bond Count80
Exact Mass2575.2959144
Monoisotopic Mass2574.2925596
Topological Polar Surface Area1140 Ų
Heavy Atom Count181
Formal Charge0
Complexity6050
Isotope Atom Count0
Defined Atom Stereocenter Count26
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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