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Nemazoline (hydrochloride)

CAT: 0804-HY-106798Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106798Size:1 Each
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Description
Nemazoline hydrochloride (A-57219 hydrochloride) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline hydrochloride produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline hydrochloride also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels[1].
CAS Number
111073-18-8
Product Name Alternative
A-57219; SCH 40054
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
ClC1=C(N)C(Cl)=CC(CC2=NCCN2)=C1.Cl
Molecular Formula
C10H12Cl3N3
Molecular Weight
280.58
References & Citations
[1]DeBernardis JF, et al. A new nasal decongestant, A-57219: a comparison with oxymetazoline. J Pharm Pharmacol. 1987 Sep;39 (9) :760-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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