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Palosuran (Standard)

CAT: 0804-HY-10655R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10655R-01Size:1 mg
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Description
Palosuran (Standard) is the analytical standard of Palosuran. This product is intended for research and analytical applications. Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats[1][2].
CAS Number
540769-28-6
Product Name Alternative
ACT-058362 (Standard)
UNSPSC
12352005
Target
Reference Standards; Urotensin Receptor
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease
Smiles
OC(CC1=CC=CC=C1)(CC2)CCN2CCNC(NC3=CC(C)=NC4=CC=CC=C34)=O
Molecular Formula
C25H30N4O2
Molecular Weight
418.53
References & Citations
[1]Clozel M, et al. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2- (4-benzyl-4-hydroxy-piperidin-1-yl) -ethyl]-3- (2-methyl-quinolin-4-yl) -urea sulfate salt) : first demonstration of a pathophysiological role of the urotensin System. J Pharmacol Exp Ther. 2004 Oct;311 (1) :204-12.|[2]Clozel M, et al. The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats. J Pharmacol Exp Ther. 2006 Mar;316 (3) :1115-21.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
B1304-10Palosuran
MBS3609463-01Palosuran hydrochloride
A13300-100Palosuran 100mg
A13300-25Palosuran 25mg
A13300-200Palosuran 200mg
A13300-10Palosuran 10mg
A13300-50Palosuran 50mg
A13300-5Palosuran 5mg
A13300-2Palosuran 2mg
MBS577763ACT 058362; Palosuran

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