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RPR 130737

CAT: 0804-HY-106404Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106404Size:1 Each
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Description
RPR 130737 is a selective, potent and competitive inhibitor for factor Xa with a Ki of 2.4 nM. RPR 130737 shows selectivity of more than 1000-fold over thrombin, activated protein C, plasmin, tissue-plasminogen activator and trypsin. RPR 130737 can prolong plasma activated partial thromboplastin time and prothrombin time. RPR 130737 shows no effect on platelet aggregation. RPR 130737 can be used for the research of cardiovascular disease, such as thrombosis[1].
CAS Number
[205054-36-0]
UNSPSC
12352005
Target
Factor Xa
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N(CC1=CC(C(N)=N)=CC=C1O)CC2)[C@H]2NS(=O)(C3=CC=C(C4=CN=CC=C4)S3)=O
Molecular Formula
C21H21N5O4S2
Molecular Weight
471.55
References & Citations
[1]Chu V, et al. In vitro characterization of a novel factor Xa inhibitor, RPR 130737. Thromb Res. 2000 Jul 1;99 (1) :71-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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