E-5842 (citrate)

• Description:

  E-5842 citrate is a σ receptor ligand (Ki: 4 nM for σ1 receptor) . E-5842 citrate increases levels of Fos in the medial prefrontal cortex and the nucleus accumbens, without affecting the levels of the protein in the striatum. E-5842 citrate can be used in the research of psychiatric disorders[1].

• UNSPSC:

  12352005

• Target:

  Sigma Receptor

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  FC1=CC=C(C=C1)C2=CCN(CC2)CCCCN3N=CN=C3.O=C(O)CC(O)(CC(O)=O)C(O)=O

• Molecular Formula:

  C23H29FN4O7

• Molecular Weight:

  492.50

• References & Citations:

  [1]Guitart X, et al. The effect of E-5842, a sigma receptor ligand and potential atypical antipsychotic, on Fos expression in rat forebrain. Eur J Pharmacol. 1998 Dec 18;363 (2-3) :127-30.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Sigma 1 Receptor

• CAS Number:

  [220120-14-9]