Duazomycin (sodium)

• Description:

  Duazomycin (Duazomycin A) sodium is a glutamine antagonist. Duazomycin sodium can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity[1][2].

• Product Name Alternative:

  Duazomycin A (sodium)

• UNSPSC:

  12352211

• Target:

  Glutaminase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.11

• Solubility:

  H2O : 50 mg/mL

• Smiles:

  [N-]=[N+]=CC(CC[C@@H](C(O[Na])=O)NC(C)=O)=O

• Molecular Formula:

  C8H10N3NaO4

• Molecular Weight:

  235.17

• References & Citations:

  [1]Vogel C L, et al. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine[J]. Proceedings of the Society for Experimental Biology and Medicine, 1969, 131 (1) : 251-256.|[2]Rosenberg S, et al. Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A’[J]. Nature, 1963, 199 (4898) : 1101-1102.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2839447-07-1]