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Eniluracil (Standard)

CAT: 0804-HY-10533RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10533RSize:1 Each
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Description
Eniluracil (Standard) is the analytical standard of Eniluracil. This product is intended for research and analytical applications. Eniluracil (5-Ethynyluracil) is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil) [1][2]. Eniluracil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
59989-18-3
Product Name Alternative
5-Ethynyluracil (Standard) ; GW776C85 (Standard)
UNSPSC
12352005
Target
Biochemical Assay Reagents; Reference Standards
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C(N1)NC=C(C#C)C1=O
Molecular Formula
C6H4N2O2
Molecular Weight
136.11
References & Citations
[1]Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9 (7) :1635-49.|[2]Cao S, et al. 5-Ethynyluracil (776C85) : modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res. 1994 Mar 15;54 (6) :1507-10.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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