SRT 1720 (Standard)

• Description :

  SRT 1720 (Standard) is the analytical standard of SRT 1720. This product is intended for research and analytical applications. SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Autophagy; Reference Standards; Sirtuin

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

• Field of Research :

  Metabolic Disease

• Purity :

  99.17

• Smiles :

  O=C(NC1=C(C=CC=C1)C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=NC6=C(N=C5)C=CC=C6

• Molecular Formula :

  C25H23N7OS

• Molecular Weight :

  469.56

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450 (7170) :712-6|[2]Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov. 2012 Jun 1;11 (6) :443-61|[3]Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest. 2012 Jun 1;122 (6) :2032-45.|[4]Yu L, et al. Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, sealed storage, away from light and moisture

• Scientific Category :

  Reference Standards

• CAS Number :

  [925434-55-5]