(Z) -SU14813

• Description:

  (Z) -SU14813 is an analog of SU14813 (HY-10501) . SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT[1].

• UNSPSC:

  12352005

• Target:

  Drug Derivative; PDGFR; VEGFR

• Related Pathways:

  Others; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC2=CC=C (C=C2/C1=C/C3=C (C (C (NC[C@@H] (CN4CCOCC4) O) =O) =C (N3) C) C) F

• Molecular Formula:

  C23H27FN4O4

• Molecular Weight:

  442.48

• References & Citations:

  [1]Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5 (7) :1774-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  452105-23-6