(Z) -SU14813

• Description :

  (Z) -SU14813 is an analog of SU14813 (HY-10501) . SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT[1].

• UNSPSC :

  12352005

• Target :

  Drug Derivative; PDGFR; VEGFR

• Related Pathways :

  Others; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(C(NC[C@@H](CN4CCOCC4)O)=O)=C(N3)C)C)F

• Molecular Formula :

  C23H27FN4O4

• Molecular Weight :

  442.48

• References & Citations :

  [1]Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5 (7) :1774-82.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [452105-23-6]