SU14813

• Description :

  SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H317, H318, H334, H335, H341, H361, H370, H413

• Target :

  C-Kit; PDGFR; VEGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SU14813.html

• Purity :

  99.11

• Solubility :

  DMSO : 44 mg/mL (ultrasonic)

• Smiles :

  O=C(/C(C1=C2)=C/C3=C(C(C(NC[C@H](O)CN4CCOCC4)=O)=C(N3)C)C)NC1=CC=C2F

• Molecular Formula :

  C23H27FN4O4

• Molecular Weight :

  442.48

• Precautions :

  H315, H317, H318, H334, H335, H341, H361, H370, H413

• References & Citations :

  [1]Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5 (7) :1774-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1

• CAS Number :

  [627908-92-3]