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(R) -DRF053

CAT: 0804-HY-10380Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10380Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -DRF053 is a CDK inhibitor. (R) -DRF053 inhibits Cdk5 and promotes the formation of ductal precursor β cells. (R) -DRF053 inhibits Dil-ox-LDL uptake and CD36 gene expression induced by advanced glycation end products (AGEs) in U937 cells[1][2].
CAS Number
1056016-06-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Smiles
CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1
Molecular Formula
C23H27N7O
Molecular Weight
417.51
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Liu KC, et al. Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors. Diabetes. 2018 Jan;67 (1) :58-70.|[2]Yashima H, et al. AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. Int J Mol Sci. 2020 Dec 4;21 (23) :9263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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