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CGP35348 (Standard)

CAT: 0804-HY-103530R-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103530R-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGP35348 (Standard) is the analytical standard of CGP35348. This product is intended for research and analytical applications. CGP 35348?is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM.?CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].
CAS Number
123690-79-9
UNSPSC
12352211
Target
GABA Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=P(C(OCC)OCC)(CCCN)O
Molecular Formula
C8H20NO4P
Molecular Weight
225.22
References & Citations
[1]H R Olpe, et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors|[2]Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. |[3]A Puigcerver, et al. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40 (3) :157-62.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Cgp 35348

antagonizes both GABA-A and GABA-B receptors

CAS Number123690-79-9
PubChem CID107699
IUPAC Name3-aminopropyl(diethoxymethyl)phosphinic acid
Molecular FormulaC8H20NO4P
Molecular Weight225.22
XLogP-3.3
Topological Polar Surface Area81.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count14
Formal Charge0
Complexity182
SMILES
CCOC(OCC)P(=O)(CCCN)O
InChI
InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
InChIKey
QIIVUOWTHWIXFO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cgp 35348
CAS: 123690-79-9
CID: 107699
Formula: C8H20NO4P
MW: 225.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight225.22
XLogP3-3.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass225.11299512
Monoisotopic Mass225.11299512
Topological Polar Surface Area81.8 Ų
Heavy Atom Count14
Formal Charge0
Complexity182
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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