Motesanib (Standard)

• Description:

  Motesanib (Standard) is the analytical standard of Motesanib. This product is intended for research and analytical applications. Motesanib (AMG 706) is a potent ATP-competitive inhibitor of?VEGFR1/2/3?with?IC50s?of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret.

• Product Name Alternative:

  AMG 706 (Standard)

• UNSPSC:

  12352005

• Target:

  C-Kit; Reference Standards; VEGFR

• Related Pathways:

  Others; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=C (C1=CC=CN=C1NCC2=CC=NC=C2) NC3=CC (NCC4 (C) C) =C4C=C3

• Molecular Formula:

  C22H23N5O

• Molecular Weight:

  373.45

• References & Citations:

  [1]Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer R|[2]Kruser TJ, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res, 2010, 16 (14), 3639-3647.|[3]Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15 (1), 110-118.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  453562-69-1