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HBX 41108 (Standard)

CAT: 0804-HY-101666RSize: 1 EachDry Ice: NoHazardous: No
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Description
HBX 41108 (Standard) is the analytical standard of HBX 41108. This product is intended for research and analytical applications. HBX 41108 is an inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. BX 41108 can be used in cancer and diabetes research[1][2][3][4].
CAS Number
924296-39-9
Target
Apoptosis; Deubiquitinase; MDM-2/p53; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer; Metabolic Disease
Smiles
N#CC1=C(C#N)N=C2C(C(C3=C2C=CC(Cl)=C3)=O)=N1
Molecular Formula
C13H3ClN4O
Molecular Weight
266.64
References & Citations
[1]Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8 (8) :2286-95. |[2]Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5 (4) :552-8. |[3]Li X, Wang T, et al. Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53. Acta Biochim Biophys Sin (Shanghai) . 2022 Mar 25;54 (3) :311-320. |[4]Li X, Wang T, et al. Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53. Acta Biochim Biophys Sin (Shanghai) . 2022 Mar 25;54 (3) :311-320. |[5]Nawa Y, et al. Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression. J Neurochem. 2017 Sep;142 (6) :827-840.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
MBS3616018-01HBX 41108
407460HBX-41108
A13352-25HBX 41108 25mg
A13352-5HBX 41108 5mg
A13352-10HBX 41108 10mg
A13352-2HBX 41108 2mg
A13352-100HBX 41108 100mg
A13352-50HBX 41108 50mg
A13352-1HBX 41108 1mg
abx098967-01Standard

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