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Roblitinib (Standard)

CAT: 0804-HY-101568RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101568RSize:1 Each
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Description
Roblitinib (Standard) is the analytical standard of Roblitinib. This product is intended for research and analytical applications. Roblitinib (FGF-401) is an orally active and highly selective FGFR4 inhibitor with an IC50 of 1.9 nM[1]. Roblitinib has antitumor activity[2].
CAS Number
1708971-55-4
Target
FGFR; Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN1CC(N(CC2=CC(CCCN3C(NC4=CC(NCCOC)=C(C#N)C=N4)=O)=C3N=C2C=O)CC1)=O
Molecular Formula
C25H30N8O4
Molecular Weight
506.56
References & Citations
[1]Nicole Buschmann, et al. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO2015059668A1.|[2]Robin A Fairhurst, et al. Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4. J Med Chem. 2020 Nov 12;63 (21) :12542-12573.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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