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Onametostat (Standard)

CAT: 0804-HY-101564RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101564RSize:1 Each
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Description
Onametostat (Standard) is the analytical standard of Onametostat. This product is intended for research and analytical applications. Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer[1][2].
CAS Number
2086772-26-9
Target
Histone Methyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1
Molecular Formula
C22H23BrN6O2
Molecular Weight
483.36
References & Citations
[1]Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.|[2]Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo) . 2019;67 (4) :382-388.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
A9936-10Onametostat
S8624-10mM/1mLOnametostat (JNJ-64619178)
A16861-50Onametostat (JNJ-64619178) 50mg
A16861-25Onametostat (JNJ-64619178) 25mg
A16861-1Onametostat (JNJ-64619178) 1mg
A16861-5Onametostat (JNJ-64619178) 5mg
A16861-100Onametostat (JNJ-64619178) 100mg
A16861-10Onametostat (JNJ-64619178) 10mg
A16861-2Onametostat (JNJ-64619178) 2mg
A16861-10mM-DOnametostat (JNJ-64619178) 10mM * 1mL in DMSO

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