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Onametostat

CAT: 0804-HY-101564-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101564-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer[1][2].
CAS Number
2086772-26-9
Product Name Alternative
JNJ-64619178
UNSPSC
12352005
Hazard Statement
H302, H319, H332, H372, H400
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/onametostat.html
Purity
99.83
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1
Molecular Formula
C22H23BrN6O2
Molecular Weight
483.36
Precautions
H302, H319, H332, H372, H400
References & Citations
[1]Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.|[2]Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo) . 2019;67 (4) :382-388.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PRMT5

Alternative Products

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A9936-10Onametostat
S8624-10mM/1mLOnametostat (JNJ-64619178)
A16861-50Onametostat (JNJ-64619178) 50mg
A16861-25Onametostat (JNJ-64619178) 25mg
A16861-1Onametostat (JNJ-64619178) 1mg
A16861-5Onametostat (JNJ-64619178) 5mg
A16861-100Onametostat (JNJ-64619178) 100mg
A16861-10Onametostat (JNJ-64619178) 10mg
A16861-2Onametostat (JNJ-64619178) 2mg
A16861-10mM-DOnametostat (JNJ-64619178) 10mM * 1mL in DMSO

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