Linrodostat (Standard)

• Description :

  Linrodostat (Standard) is the analytical standard of Linrodostat (HY-101560) . This product is intended for research and analytical applications. Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers[1][2].

• Target :

  Indoleamine 2,3-Dioxygenase (IDO) ; Reference Standards

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(NC1=CC=C(Cl)C=C1)[C@H](C)[C@@](CC2)([H])CC[C@H]2C3=CC=NC4=C3C=C(F)C=C4

• Molecular Formula :

  C24H24ClFN2O

• Molecular Weight :

  410.91

• References & Citations :

  [1]Richards T, et al. Cell based functional assays for IDO1 inhibitor screening and characterization. Oncotarget. 2018 Jul 20;9 (56) :30814-30820.|[2]Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl) : Abstract nr CT116.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [1923833-60-6]