A-395 (Standard)

CAT: 0804-HY-101512RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101512RSize:1 Each
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Description
A-395 (Standard) is the analytical standard of A-395 (HY-101512) . This product is intended for research and analytical applications. A-395, a chemical probe, is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM[1].
CAS Number
[2089148-72-9]
Target
Histone Methyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
O=S(N1CCN(C2=CC=C([C@H]3CN(C4C(C(F)=CC=C5)=C5CC4)C[C@@H]3N(C)C)C=C2)CC1)(C)=O
Molecular Formula
C26H35FN4O2S
Molecular Weight
486.65
References & Citations
[1]He Y, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13 (4) :389-395.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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