A-395 (Standard)

• Description :

  A-395 (Standard) is the analytical standard of A-395 (HY-101512) . This product is intended for research and analytical applications. A-395, a chemical probe, is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM[1].

• Target :

  Histone Methyltransferase; Reference Standards

• Related Pathways :

  Epigenetics; Others

• Field of Research :

  Cancer

• Smiles :

  O=S(N1CCN(C2=CC=C([C@H]3CN(C4C(C(F)=CC=C5)=C5CC4)C[C@@H]3N(C)C)C=C2)CC1)(C)=O

• Molecular Formula :

  C26H35FN4O2S

• Molecular Weight :

  486.65

• References & Citations :

  [1]He Y, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13 (4) :389-395.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [2089148-72-9]