A-395

• Description :

  A-395, a chemical probe, is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/A-395.html

• Purity :

  99.12

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=S(N1CCN(C2=CC=C([C@H]3CN(C4C(C(F)=CC=C5)=C5CC4)C[C@@H]3N(C)C)C=C2)CC1)(C)=O

• Molecular Formula :

  C26H35FN4O2S

• Molecular Weight :

  486.65

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]He Y, et al. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13 (4) :389-395.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EZH2

• CAS Number :

  [2089148-72-9]