E7090 (Standard)

• Description:

  E7090 (Standard) is the analytical standard of E7090 (HY-101466) . This product is intended for research and analytical applications. E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively[1].

• Target:

  FGFR; Reference Standards

• Related Pathways:

  Others; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=C(N1C=CC2=C1C=C(OCCOC)C(OC3=CC(NC(C4=CC=C(C5CCN(CCO)CC5)C=C4)=O)=NC=C3)=C2)NC

• Molecular Formula:

  C32H37N5O6

• Molecular Weight:

  587.67

• References & Citations:

  [1]Saori Watanabe Miyano, et al. E7090: A potent and selective FGFR inhibitor with activity in multiple FGFR-driven cancer models with distinct mechanisms of activation. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.|[2]Saori Watanabe Miyano, et al. E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models. Mol Cancer Ther. 2016 Nov;15 (11) :2630-2639.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [1622204-21-0]