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E7090 (Standard)

CAT: 0804-HY-101466RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101466RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E7090 (Standard) is the analytical standard of E7090. This product is intended for research and analytical applications. E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively[1].
CAS Number
1622204-21-0
Target
FGFR; Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N1C=CC2=C1C=C(OCCOC)C(OC3=CC(NC(C4=CC=C(C5CCN(CCO)CC5)C=C4)=O)=NC=C3)=C2)NC
Molecular Formula
C32H37N5O6
Molecular Weight
587.67
References & Citations
[1]Saori Watanabe Miyano, et al. E7090: A potent and selective FGFR inhibitor with activity in multiple FGFR-driven cancer models with distinct mechanisms of activation. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.|[2]Saori Watanabe Miyano, et al. E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models. Mol Cancer Ther. 2016 Nov;15 (11) :2630-2639.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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