Adaptaquin

• Description :

  Adaptaquin is a BBB-penetrable HIF-PHDs inhibitor. Adaptaquin has anti-inflammatory and neuroprotective effects. Adaptaquin can effectively inhibit lipid peroxidation, maintain mitochondrial function, and reduce neuronal death. Adaptaquin can be used in the research of nervous system diseases such as Parkinson's disease[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/adaptaquin.html

• Concentration :

  10mM

• Purity :

  99.87

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(Cl)C=C3)NC4=NC=CC=C4O

• Molecular Formula :

  C21H16ClN3O2

• Molecular Weight :

  377.82

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7 (5) :e2214.|[2]Aimé P, et al. The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiol Dis. 2020 Mar;136:104725.|[3]Karuppagounder SS, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016 Mar 2;8 (328) :328ra29.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [385786-48-1]