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Cyclo (his-pro) (TFA) (Standard)

CAT: 0804-HY-101402ARSize: 1 EachDry Ice: NoHazardous: No
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Description
Cyclo (his-pro) (TFA) (Standard) is the analytical standard of Cyclo (his-pro) (TFA) . This product is intended for research and analytical applications. Cyclo (his-pro) TFA (Cyclo (histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo (his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo (his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].
CAS Number
936749-56-3
Product Name Alternative
Cyclo (histidyl-proline) (TFA) (Standard) ; Histidylproline diketopiperazine (TFA) (Standard)
UNSPSC
12352005
Target
Endogenous Metabolite; NF-κB; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
OC(C(F)(F)F)=O.O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O
Molecular Formula
C13H15F3N4O4
Molecular Weight
348.28
References & Citations
[1]Grottelli S, et al. The Role of Cyclo (His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17 (8) . pii: E1332.|[2]Minelli A, et al. Cyclo (His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44 (3) :525-35.|[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo (His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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