2-Iodomelatonin (Standard)

• Description:

  2-Iodomelatonin (Standard) is the analytical standard of 2-Iodomelatonin. This product is intended for research and analytical applications. 2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 ?over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

• UNSPSC:

  12352005

• Target:

  Melatonin Receptor; Reference Standards

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research:

  Cancer

• Smiles:

  CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O

• Molecular Formula:

  C13H15IN2O2

• Molecular Weight:

  358.17

• References & Citations:

  [1]Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166 (9) :5792-800.|[2]Wang X, et al. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.J Neurosci. 2011 Oct 12;31 (41) :14496-507.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [93515-00-5]