2-Iodomelatonin

• Description:

  2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

• UNSPSC:

  12352005

• Target:

  Melatonin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-iodomelatonin.html

• Purity:

  99.04

• Solubility:

  DMF : 30 mg/mL (ultrasonic; warming) |DMSO : 30 mg/mL (ultrasonic; warming) |Ethanol : 20 mg/mL (ultrasonic; warming)

• Smiles:

  CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O

• Molecular Formula:

  C13H15IN2O2

• Molecular Weight:

  358.17

• References & Citations:

  [1]Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166 (9) :5792-800.|[2]Wang X, et al. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.J Neurosci. 2011 Oct 12;31 (41) :14496-507.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MT1

• CAS Number:

  [93515-00-5]